Definitions

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  • n. A protein important in the contraction of striated muscle tissues.

Etymologies

Sorry, no etymologies found.

Examples

  • "A hallmark of titin-like proteins is that they unfold under a stretching force to dissipate energy and prevent damage to tissues by over-stretching," said co-author John

    BBC News | News Front Page | World Edition

  • Researchers engineered a polymer to reproduce the properties of titin - a protein which largely determines the elastic properties of muscle.

    BBC News | News Front Page | World Edition

  • The team engineered a synthetic protein to reproduce the molecular structure of titin, the muscle protein "that largely governs the elastic properties of muscle," according to the Nature article.

    PhysOrg.com - latest science and technology news stories

  • The authors wrote that synthetic biomaterials display the unique multifunctional characteristics of titin, acting like a spring with high resilience at low strain and as a shock-absorb at high strains.

    PhysOrg.com - latest science and technology news stories

  • N2BA: the large more compliant isoform (3300 kDa) of titin, N2B: the smaller stiffer isoform (3000 kDa) of titin, nebulin

    PLoS ONE Alerts: New Articles

  • D, gel electrophoresis and densitometric analysis showing lowered titin protein levels and its isoforms in hypoxic E20 chick embryo hearts.

    PLoS ONE Alerts: New Articles

  • Hypoxic chick embryos displayed severe LV dilatation just prior to hatching, which was accompanied by a reduced LV wall mass, increased apoptosis, as well as a lowered cardiac content of the sarcomeric proteins MHC and titin.

    PLoS ONE Alerts: New Articles

  • Trombitas K, Witt CC, Labeit S, et al. (2002) Changes in titin isoform expression in pacing-induced cardiac failure give rise to increased passive muscle stiffness.

    PLoS ONE Alerts: New Articles

  • The integrated optical density (OD) of N2BA titin, N2B titin, total titin (N2BA+N2B), and myosin heavy chain (MHC) were determined at each lane.

    PLoS ONE Alerts: New Articles

  • The increase in the interstitial protein collagen and decrease in the sarcomeric proteins MHC and titin in hypoxic hearts might account for the observed changes

    PLoS ONE Alerts: New Articles

Comments

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  • The word is a play on the Greek, "titan," a giant being, because the molecule of this protein is large. The discoverers of the molecule gave it this name in their scientific paper

    April 29, 2015

  • There is an even shorter form: spam.

    April 11, 2011

  • Bravo.

    April 11, 2011

  • it's actually even larger, i can't fit it all here

    August 1, 2008

  • Titin is the longest word in the English language. It's real name is:

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alanylisoleucylcysteinylprolylprolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutami nylisoleucylalanylseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalany lglycylvalylthreonylglycylalanylglutamylasparaginylarginylalanylalanylleucylprolylleucylasparaginylh istidylleucylvalylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolylleucylglut aminylglycylphenylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanylalanylisol eucylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysyli soleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllysylmethionyll eucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmethionyllysylalanylalanylthreonyl arginylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylphenylalanylvalylphenylalan 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ucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylthreonylphenylalany lglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylalanyltitinmethionyl glutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylprolylaspartyla lanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycylarginylgl ycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamylaspar aginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylgluta myltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylseryla lanylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylal anylisoleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylas paraginylisoleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanyl valylglutaminylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreon ylserylprolylserylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspart ylprolylisoleucylglutamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparagi nylglutaminylphenylalanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutamin ylvalylglutaminylglutaminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylgl utaminylserylthreonylvalylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginy ltyrosylasparaginylalanylvalylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthr eonylphenylalanylaspartylthreonylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasp araginylglutaminylglutaminylserylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthr eonylarginylarginylvalylaspartylaspartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparagi nylisoleucylasparaginylleucylvalylasparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyr osylasparaginylglutaminylasparaginylthreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyl tryptophylthreonylserylalanylprolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylph enylalanylalanylisoleucylcysteinylprolylprolylaspartylalanylaspartylaspartylaspartylleucylleucylargi nylglutaminylisoleucylalanylseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucylserylar ginylalanylglycylvalylthreonylglycylalanylglutamylasparaginylarginylalanylalanylleucylprolylleucylas paraginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolyl leucylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanyl alanylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisoleucylv alyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllysyl methionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmethionyllysylalanylalan ylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylphenylalanylvalyl phenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucylleucylasparagi nylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenylalanylglutaminylthreonylgl utaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylphenylalanylserylg lutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylphenylalanyl 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larginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglu tamylasparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyl lysylglutamyltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisole ucylserylalanylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalan ylglycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminyl histidylasparaginylisoleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylph enylalanylvalylglutaminylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisole ucylthreonylserylprolylserylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylal anylaspartylprolylisoleucylglutamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglyc ylasparaginylglutaminylphenylalanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreon ylglutaminylvalylglutaminylglutaminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalan ylprolylglutaminylserylthreonylvalylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyr osylarginyltyrosylasparaginylalanylvalylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucy lglycylthreonylphenylalanylaspartylthreonylarginylasparaginylarginylisoleucylisoleucylglutamylvalylg lutamylasparaginylglutaminylglutaminylserylprolylthreonylthreonylalanylglutamylthreonylleucylasparty lalanylthreonylarginylarginylvalylaspartylaspartylalanylthreonylvalylalanylisoleucylarginylserylalan ylasparaginylisoleucylasparaginylleucylvalylasparaginylglutamylleucylvalylarginylglycylthreonylglycy lleucyltyrosylasparaginylglutaminylasparaginylthreonylphenylalanylglutamylserylmethionylserylglycyll eucylvalyltryptophylthreonylserylalanylprolylalanyltitinmethionylglutaminylarginyltyrosylglutamylser ylleucylphenylalanylalanylmethionylthreonylthreonylglutaminylarginyltyrosylglutamylserylleucylphenyl alanylalanylglutaminylleucyllysylglutamylarginyllysylglutamylglycylalanylphenylalanylvalylprolylphen ylalanylvalylthreonylleucylglycylaspartylprolylglycylisoleucylglutamylglutaminylserylleucyllysylisol eucylaspartylthreonylleucylisoleucylglutamylalanylglycylalanylaspartylalanylleucylglutamylleucylglyc ylisoleucylprolylphenylalanylserylaspartylprolylleucylalanylaspartylglycylprolylthreonylisoleucylglu taminylasparaginylalanylthreonylleucylarginylalanylphenylalanylalanylalanylglycylvalylthreonylprolyl alanylglutaminylcysteinylphenylalanylglutamylmethionylleucylalanylleucylisoleucylarginylglutaminylly sylhistidylprolylthreonylisoleucylprolylisoleucylglycylleucylleucylmethionyltyrosylalanylasparaginyl leucylvalylphenylalanylasparaginyllysylglycylisoleucylaspartylglutamylphenylalanyltyrosylalanylgluta minylcysteinylglutamyllysylvalylglycylvalylaspartylserylvalylleucylvalylalanylaspartylvalylprolylval ylglutaminylglutamylserylalanylprolylphenylalanylarginylglutaminylalanylalanylleucylarginylhistidyla sparaginylvalylalanylprolylisoleucylphenylalanylisoleucylcysteinylprolylprolylaspartylalanylaspartyl aspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycylarginylglycyltyrosylth reonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamylasparaginylarginyl alanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosylasp araginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolylas partylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucyl serylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginylisol eucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutamin ylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolyl serylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisole ucylglutamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminyl phenylalanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutam inylglutaminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylseryl threonylvalylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylaspar aginylalanylvalylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylal anylaspartylthreonylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylgluta minylglutaminylserylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginyla rginylvalylaspartylaspartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucyla sparaginylleucylvalylasparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparagin ylglutaminylasparaginylthreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthr eonylserylalanylprolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylala nylisoleucylcysteinylprolylprolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutaminyl isoleucylalanylseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylgl ycylvalylthreonylglycylalanylglutamylasparaginylarginylalanylalanylleucylprolylleucylasparaginylhist idylleucylvalylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolylleucylglutami nylglycylphenylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanylalanylisoleuc ylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysylisol eucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllysylmethionylleuc ylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmethionyllysylalanylalanylthreonylarg inylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylphenylalanylvalylphenylalanyll eucylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucylleucylasparaginylvalylcyste inylthreonylserylserylleucylglycylasparaginylglutaminylphenylalanylglutaminylthreonylglutaminylgluta minylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylphenylalanylserylglutaminylvaly ltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylphenylalanylprolylglycyla spartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylvalylleucylaspartylprolylleucylis oleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreonylarginylasparaginylarginyl isoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylserylprolylthreonylthreonylala nylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartylaspartylalanylthreonylvaly lalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalylasparaginylglutamylleucy lvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylthreonylphenylalanylgl utamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylalanyltitinmethionylglu taminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylprolylaspartylalan ylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycylarginylglycy ltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamylasparagi nylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylglutamyl tyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylalan ylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalany lisoleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylaspar aginylisoleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylval ylglutaminylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonyls erylprolylserylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylp rolylisoleucylglutamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginyl glutaminylphenylalanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylv alylglutaminylglutaminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylgluta minylserylthreonylvalylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginylty rosylasparaginylalanylvalylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreon ylphenylalanylaspartylthreonylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylaspara ginylglutaminylglutaminylserylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreon ylarginylarginylvalylaspartylaspartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginyl isoleucylasparaginylleucylvalylasparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosy lasparaginylglutaminylasparaginylthreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltry ptophylthreonylserylalanylprolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylpheny lalanylalanylisoleucylcysteinylprolylprolylaspartylalanylaspartylaspartylaspartylleucylleucylarginyl glutaminylisoleucylalanylseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucylserylargin ylalanylglycylvalylthreonylglycylalanylglutamylasparaginylarginylalanylalanylleucylprolylleucylaspar aginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolylleu cylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanylala nylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisoleucylvaly llysylisoleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllysylmet hionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmethionyllysylalanylalanylt hreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylphenylalanylvalylphe nylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucylleucylasparaginyl valylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenylalanylglutaminylthreonylgluta minylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylphenylalanylserylglut aminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylphenylalanylpro lylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylvalylleucylaspartylprol ylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreonylarginylasparagi nylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylserylprolylthreonylt hreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartylaspartylalanylth reonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalylasparaginylglu tamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylthreonylphen ylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylalanyltitinme thionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylmethionylthreonylthreonylglutami nylarginyltyrosylglutamylserylleucylphenylalanylalanylglutaminylleucyllysylglutamylarginyllysylgluta mylglycylalanylphenylalanylvalylprolylphenylalanylvalylthreonylleucylglycylaspartylprolylglycylisole ucylglutamylglutaminylserylleucyllysylisoleucylaspartylthreonylleucylisoleucylglutamylalanylglycylal anylaspartylalanylleucylglutamylleucylglycylisoleucylprolylphenylalanylserylaspartylprolylleucylalan 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onylglycylalanylglutamylasparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylval ylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphen ylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylala nylglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucy lglutamylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllysylmethionylleucylalanylalany lleucyllysylvalylphenylalanylvalylglutaminylprolylmethionyllysylalanylalanylthreonylarginylacetylser yltyrosylserylisoleucylthreonylserylprolylserylglutaminylphenylalanylvalylphenylalanylleucylserylser ylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucylleucylasparaginylvalylcysteinylthreonyls erylserylleucylglycylasparaginylglutaminylphenylalanylglutaminylthreonylglutaminylglutaminylalanylar 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    August 1, 2008