AP-1

When transcription factors such as AP-1 are activated, they produce and release collagen-digesting proteins matrix metalloproteinase, resulting in microscarring in the deep portion of the skin called the dermis.

Forever Young M.D. Nicholas Perricone 2010

As you will learn in “The Birth of a Wrinkle,” on page 60, activation of NFκB and AP-1 leads to inflammation-related microscarring of collagen, resulting in wrinkles.

Forever Young M.D. Nicholas Perricone 2010

One of the most important is its ability to prevent the activation of pro-inflammatory transcription factors such as NFκB and AP-1.

Forever Young M.D. Nicholas Perricone 2010

This activates transcription factors such as NFκB and AP-1.

Forever Young M.D. Nicholas Perricone 2010

In this chapter we are going to introduce substances that turn off disease and age-accelerating transcription factors such as NFκB and AP-1 and turn on the age- and disease-fighting transcription factor NRF2.

Forever Young M.D. Nicholas Perricone 2010

When transcription factors such as AP-1 are activated, they produce and release collagen-digesting proteins matrix metalloproteinase, resulting in microscarring in the deep portion of the skin called the dermis.

Forever Young M.D. Nicholas Perricone 2010

This activates transcription factors such as NFκB and AP-1.

Forever Young M.D. Nicholas Perricone 2010

They prevent the oxidation of lipids in the cell plasma membrane, blocking the production of arachidonic acid, while at the same time inhibiting the activation of the transcription factors NFκB and AP-1.

Forever Young M.D. Nicholas Perricone 2010

It also protects against inflammation by inhibiting the pro-inflammatory transcription factors such as NFκB and AP-1.

Forever Young M.D. Nicholas Perricone 2010

Like alpha-lipoic acid (ALA), curcumin inhibits the pro-inflammatory actions of nuclear factor kappa-B (NFκB) and activator protein 1 (AP-1).

Forever Young M.D. Nicholas Perricone 2010