Definitions
American Heritage® Dictionary of the English Language, Fourth Edition
- n. A gene that is associated with the development of familial breast cancer when inherited in a defective state.
Etymologies
- br(east) ca(ncer) 1. (American Heritage® Dictionary of the English Language, Fourth Edition)
Examples
“BRCA1 is believed to be a tumor suppressor gene (Ormitom, 1996).”
“BRCA1 is also associated with the predisposition to ovarian cancer.”
“The life time risk of breast cancer in BRCA1 mutations carriers is about 70% by the age 70 years.”
“The findings run counter to an influential 2007 study, which found that such women could have as much as a five-fold higher risk of developing the disease as the general population, even if they tested negative for the two genetic mutations known as BRCA1 and BRCA2.”
The Wall Street Journal: Study Weakens Case for Preventive Mastectomy
“Known as BRCA1 and 2, the genes naturally occur on chromosomes amid tens of millions of other basic DNA building blocks, or nucleotides.”
The Wall Street Journal: In Reversal, Court Rules Human Gene Can Be Patented
“Although one can't be certain, it is likely that all of their cancers, each and every one, were due to a mutation known as BRCA1.185delAG.”
“The results apply to the general population, not to women who carry genetic mutations known as BRCA1 or 2 that raise their risk of breast cancer.”
USA Today: Mammogram schedule should be customized, study finds
“It has a dominant position in testing for the two genes, called BRCA1 and BRCA2, and big insurers cover its tests.”
“Actually, if a female has mutations in certain tumor-suppressing genes called BRCA1 or BRCA2, many doctors recommend just that, along with an oophorectomy, as the chances of getting breast cancer for women with those gene mutations in their lifetime are something like 60% — 5 times higher than for the general population at 12%.”
“In a nonrandomized study of 52 women with cancer caused by mutations in genes known as BRCA1 and BRCA2, the agent given alone caused tumors to shrink significantly in as much as 41% of participants.”
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