Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any of a group of cation channels specific to sperm

Etymologies

Sorry, no etymologies found.

Examples

  • Thus, to maintain hyperactivation, sperm require both open CatSper channels and available external Ca Fig. 5A we asked whether removal of HC-0546456 would allow previously-hyperactivated sperm to recover waveform asymmetry.

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  • Fig. S2A shows that smaller CatSper currents could be recorded from cells bathed with solutions containing 700 nM Ca

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  • Thus, open CatSper channels and entry of external Ca

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  • Specifically, we show that acute blockade of CatSper channels with compound HC-056456 prevents the onset of hyperactivation during capacitating incubations, and that application of HC-056456 to already-hyperactivated sperm causes a rapid reversible removal of waveform asymmetry.

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  • However, the delayed and asynchronous onset of hyperactivation has obscured whether CatSper channels are required for hyperactivation to initiate, for it to be sustained, or for both.

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  • In addition to the pharmacological-phenocopy approach used here for study of the roles of CatSper in activation and hyperactivation of motility, we recently applied a chemical-genetic approach to extend our knowledge of the roles of PKA in the these processes.

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  • (B) History plot showing rapid and reversible block of CatSper currents by 20 ┬ÁM HC-056456 in buffer containing ~700 nM free Ca

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  • For CatSper currents recording conditions were essentially as described in Kirichok, et al. [15].

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  • Electrophysiological recording of CatSper and KSper currents

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  • Suarez SS (2009) CatSper-null mutant spermatozoa are unable to ascend beyond the oviductal reservoir.

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