GM-CSF

In preliminary safety studies Knuth's group has injected GM-CSF directly into melanoma patients and then vaccinated them with peptides from several differentiation antigens.

Vaccinating Against Cancer 1997

In this approach researchers insert the gene for a cytokine, or signaling molecule, known as GM-CSF (for "granulocyte macrophage colony stimulating factor") into irradiated tumor cells and inject these cells back into patients, so that the disabled cancer cells will send a message recruiting helper T cells to the tumor.

Vaccinating Against Cancer 1997

The FBP vaccine consists of the E39 peptide combined with the immune adjuvant granulocyte macrophage colony stimulating factor GM-CSF.

unknown title 2011

The FBP vaccine consists of the E39 peptide derived from the folate binding protein combined with the immune adjuvant granulocyte macrophage colony stimulating factor GM-CSF.

unknown title 2011

And separately, we have decided not to proceed with the OncoVEX GM-CSF Phase III program in squamous cell carcinoma of the head and neck.

unknown title 2011

NeuVax consists of the E75 peptide derived from human epidermal growth factor receptor 2 (HER2) combined with the immune adjuvant granulocyte macrophage colony-stimulating factor (GM-CSF).

unknown title 2011

I'm pleased to report that the Phase III clinical study of OncoVEX GM-CSF for the treatment of stage 3, 4 malignant melanoma has completed enrollment.

unknown title 2011

Its most advanced program MOR103, a first-in-class, fully human antibody against GM-CSF, is currently being tested in a Phase Ib/IIa trial in rheumatoid arthritis patients.

Reuters: Press Release 2011

Obviously, our approach to new indications for OncoVEX GM-CSF will take into account what we have learned through the conduct of our melanoma trial.

unknown title 2011

In future research, Dr. Vlahos hopes to test whether GM-CSF could be a key target in other disease processes.

PhysOrg.com - latest science and technology news stories PhysOrg Team 2010