“In preliminary safety studies Knuth's group has injected GM-CSF directly into melanoma patients and then vaccinated them with peptides from several differentiation antigens.”
“In this approach researchers insert the gene for a cytokine, or signaling molecule, known as GM-CSF (for "granulocyte macrophage colony stimulating factor") into irradiated tumor cells and inject these cells back into patients, so that the disabled cancer cells will send a message recruiting helper T cells to the tumor.”
“Its most advanced program MOR103, a first-in-class, fully human antibody against GM-CSF, is currently being tested in a Phase Ib/IIa trial in rheumatoid arthritis patients.”
“In future research, Dr. Vlahos hopes to test whether GM-CSF could be a key target in other disease processes.”
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