IL-7

Brown, MD, PhD is characterizing the ways in which interference with IL-7 signaling can be used as a therapeutic strategy in pediatric ALL.

Pediatric cancer research 2010

Another region harbors a gene called the IL-7 receptor, which helps to control the activity of a class of immune cells called regulatory T cells.

Link Between MS and Other Autoimmune Disease | Impact Lab 2007

Two papers appearing simultaneously in Nature Genetics confirm this finding, and explore how the change in the IL-7 receptor affects the immune system. “I believe that this receptor and its interaction with regulatory T cells will now become a major focus of research on MS,” says Stephen Hauser, professor of neurology at University of California San Francisco, and another author on the paper.

Link Between MS and Other Autoimmune Disease | Impact Lab 2007

Due to its profound impact on the homeostatic levels of T cells and lack of toxicity in vivo, IL-7 therapy is currently being used in clinical trials as a means to bolster T cell levels in lymphopenic individuals

PLoS ONE Alerts: New Articles Ryan M. O'Connell et al. 2010

Testing of various conditions revealed that reduction of the cytokine interleukin-7 (IL-7), possibly corresponding to an environmental signal in the thymus, triggered resumption of development and differentiation into T cells.

PRWeb - Daily News Feed 2010

These data suggest that the non-redundant requirement for IL-7 and IL-15 is mediated through differential activation of both STAT5-dependent and STAT5-independent pathways.

Naturejobs - All Jobs Roslyn A Kemp 2010

Interestingly, WT-STAT5a expression enhanced memory formation in a strictly IL-7-dependent manner, suggesting that IL-7 is a more potent activator of STAT5 than IL-15 in vivo.

Naturejobs - All Jobs Roslyn A Kemp 2010

Lacabaratz C, Weiss L, Viard JP, Goujard C, et al. (2009) Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment.

PLoS ONE Alerts: New Articles Ryan M. O'Connell et al. 2010

To determine whether STAT5 activity was required for IL-7 and IL-15-mediated generation of memory, we expressed either wild type (WT) or constitutively active (CA) forms of STAT5a in normal effector cells and then observed their ability to form memory in cytokine replete or deficient hosts.

Naturejobs - All Jobs Roslyn A Kemp 2010

Placing the final piece in the puzzle, the researchers discovered that T cell progenitors in the thymus from mice deficient in the gene Bcl11b exhibited the same halted development and self-renewal cycle, while further experiments connected up-regulation of the transcription factor encoded by this gene to IL-7 levels.

PRWeb - Daily News Feed 2010