INa

LORENZEN DROVE HOME INa daze, adhering strictly to the speed limit, expecting any minute to hear sirens and see a red bubble light in his rearview.

Foul Lines Jack McCallum 2006

LORENZEN DROVE HOME INa daze, adhering strictly to the speed limit, expecting any minute to hear sirens and see a red bubble light in his rearview.

Foul Lines Jack McCallum 2006

(B) Representative peak magnitude INa traces at baseline, after ATX-II saturation, and after washout of ATX-II followed by 20 min exposure to saline (top) or ACTH (bottom).

PLoS Biology: New Articles Michael R. Markham et al. 2009

We then investigated the signal transduction pathway by which ACTH increases the magnitude of INa.

PLoS Biology: New Articles Michael R. Markham et al. 2009

Voltage of peak INa was unchanged in both control and ACTH-treated cells (paired t-test, df = 4, p > 0.3 for both saline and ACTH). doi: 10.1371/journal. pbio.1000203.g005

PLoS Biology: New Articles Michael R. Markham et al. 2009

Disrupting vesicular trafficking prevents the ACTH-induced increase in INa.

PLoS Biology: New Articles Michael R. Markham et al. 2009

The effect of ACTH on INa amplitude was as rapid as for the whole cell AP, with marked amplitude increase apparent after 5 min, the first time point sampled.

PLoS Biology: New Articles Michael R. Markham et al. 2009

Reduction of INa by CQ and NEM could result from interference with the trafficking of either Na

PLoS Biology: New Articles Michael R. Markham et al. 2009

ACTH promotes recovery of fast INa inactivation following ATX-II treatment.

PLoS Biology: New Articles Michael R. Markham et al. 2009

(INa) were isolated by adding 50 mM TEA to the saline, and potassium currents were isolated by addition of 1 µM TTX.

PLoS Biology: New Articles Michael R. Markham et al. 2009