PCa

AR (A1675T) allele to early-onset and/or familial PCa in African Americans.

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Race, family history and age are the unequivocally accepted risk factors for prostate cancer (PCa).

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Not only can the LNCaP and C4-2 PCa progression model be applied for investigating androgen-refractory progression, but it can also be used to explore the development of radiation resistance in PCa.

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We identified a germline AR (A1675T) (T559S) substitution mutation in the DNA-binding domain in three PCa-affected members of an African-American family with a history of early-onset disease.

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AR germline mutation in an African-American family with a history of familial PCa.

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AR in association with familial PCa in African Americans who have a higher incidence and mortality rate and a clinically more aggressive disease presentation than Caucasians.

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G-1 inhibited the growth of androgen-dependent and androgen-independent prostate cancer (PCa) cells in vitro and PC-3 xenografts in vivo.

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Some cancer lines (VCaP, DuCaP, NCI-H660 and MDA-PCa 2b) failed to form spheroids, but persisted as single cells ( "single" or "singular phenotype") for up to 2 weeks.

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The discovery of this signaling pathway lays the foundation for future development of GPR30-based therapies for PCa.

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Genomic DNAs of 60 patients from 30 high-risk African American and Caucasian families participating in the Louisiana State University Health Sciences Center genetic linkage study of PCa were studied.

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