American Heritage® Dictionary of the English Language, Fourth Edition
- abbr. severe combined immunodeficiency
- n. a congenital disease affecting T cells that can result from a mutation in any one of several different genes; children with it are susceptible to infectious disease; if untreated it is lethal within the first year or two of life
“Now being added to the list: Bubble-boy disease, formally known as SCID for severe combined immune deficiency.”
“Left undiagnosed, a newborn with SCID, which is a group disorder, usually will die within the first year of life.”
“Successful use of extracorporeal membrane oxygenation (ECMO) as a bridge to reconstitution following BMT for SCID.”
“Sylvester KG, Nesbit M, Radu A, Herlyn M, Adzick NS, Crombelholme TM: Adenoviral-mediatred gene transfer in wound healing: Acute inflammatory response in human skin in the SCID mouse model.”
“Treatment of X-linked Severe Combined Immunodeficiency (X-SCID) by the in utero transplantation of paternal bone marrow.”
“In the new study, sponsored in the U.S. by investigators at Children's Hospital Boston and expected to open at five sites around the world, scientists plan to enroll 20 boys with SCID-X1, which stands for severe combined immunodeficiency, X-linked”
“Those who survived were cured of SCID-X1, but the episode prompted the U.S.”
“In the new SCID-X1 trial which is open in London and Boston and undergoing regulatory review in Los Angeles, Cincinnati and Paris researchers will take stem cells from a patient's own bone marrow, deliver a functioning gene into those cells in the lab and then infuse them back into the patient.”
“Meantime, St. Jude Children's Research Hospital, Memphis, Tenn., is planning a separate gene-therapy trial for infants with SCID-X1.”
“While gene-therapy studies in other diseases have gone forward, the new trial is the first involving SCID-X1 to take place in the U.S. since the hold.”
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