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Examples
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Although a lot less frequently observed, antibodies directed against U3RNP and Th/To are also specific for scleroderma, whereas anti-Pm/Scl, anti-Ku and anti-U1RNP antibodies are seen mainly in patients with overlap syndromes.
Naturejobs - All Jobs Svetlana I. Nihtyanova 2010
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(Scl) and the lymphoblastic leukemia gene 1 (Lyl1) - play overlapping or redundant roles in maintaining this pool of hematopoietic (blood-forming cells) stem cells.
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When the gene Scl is turned off in adult animals, blood cells are not repopulated in the short term but they do come back over the long term, the researchers noted.
PhysOrg.com - latest science and technology news stories 2009
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When blood-forming stem cells lack Scl and have only one copy of the Lyl1 gene, they can still be used successfully in a stem cell transplant, enabling animals to continue to make blood cells in the long-term.
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"Scl has been well studied and is a paradigm for hematopoiesis," she said.
PhysOrg.com - latest science and technology news stories 2009
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When blood-forming stem cells lack Scl and have only one copy of the Lyl1 gene, they can still be used successfully in a stem cell transplant, enabling animals to continue to make blood cells in the long-term.
PhysOrg.com - latest science and technology news stories 2009
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This suggests that Scl and Lyl1 are not only important in the formation of these kinds of stem cell but also for their maintenance in adults, the researchers said.
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In a report in the current issue of the journal Cell Stem Cell, the scientists show that genes for two transcription factors -- the stem cell leukemia gene (Scl) and the lymphoblastic leukemia gene 1 (Lyl1) - play overlapping or redundant roles in maintaining this pool of hematopoietic (blood-forming cells) stem cells.
PhysOrg.com - latest science and technology news stories 2009
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Previous studies had shown that when animals lacked the gene Scl in the embryonic stage, they did not make progenitor cells intrinsic to the formation of the blood cells and had defects in the blood vessel system.
PhysOrg.com - latest science and technology news stories 2009
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When the gene Scl is turned off in adult animals, blood cells are not repopulated in the short term but they do come back over the long term, the researchers noted.
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