X-chromosome

• “He tries to rationalize the mistake of being born in a boy's body, concluding that his second X-chromosome must have gotten accidentally tossed in the garbage; voices his plans to marry his friend and neighbor Jerome when he's finally not a boy; and loves dresses, makeup, and the not-Barbie-not-even-a-little-bit doll Pam.”

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• “Similarly there is a 50 percentchance that he will inherit the X-chromosome with the normal SH2D1A gene copy.”

  X-linked Lymphoproliferative Syndrome

• “The Y-chromosome in males does not contain the same genesthat are carried on the X-chromosome.”

  X-linked Lymphoproliferative Syndrome

• “Since males have a single X-chromosome, they have only one copy of the SH2D1A gene.”

  X-linked Lymphoproliferative Syndrome

• “If a man with X-linked lymphoproliferative syndrome (and hence an SH2D1A alteration) has children with a female partner who does not carry an alteration in SH2D1A, he will either pass on a Y-chromosome to his sons (who will therefore be unaffected by the syndrome) or he will pass the X-chromosome with the SH2D1A alteration to his daughters (who will be X-linked lymphoproliferative syndrome carriers).”

  X-linked Lymphoproliferative Syndrome

• “If a woman has one X-chromosome with an alteration in SH2D1A and her other X-chromosome has a normal SH2D1A gene, she is said to be a “carrier.””

  X-linked Lymphoproliferative Syndrome

• “This female carrier, however, can pass her X-chromosome with the SH2D1A alteration to a proportion of her future children.”

  X-linked Lymphoproliferative Syndrome

• “This is because she will have one X-chromosome with an alteration in the SH2D1A gene (inherited from her mother) and one X-chromosome with a normal copy of the SH2D1A gene (inherited from her father).”

  X-linked Lymphoproliferative Syndrome

• “A male child will always receive an X-chromosome from his mother and a Y-chromosome from his father.”

  X-linked Lymphoproliferative Syndrome

• “Females have two X-chromosomes, whereas males have one X-chromosome and one Y-chromosome.”

  X-linked Lymphoproliferative Syndrome

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