“I ended the monthly infusions from the abatacept study I was in with Trialnet in February.”
“For those who cannot take rituximab for some reason, they can try one of the four other anti-TNFs, called adalimumab, etanercept, infliximab and abatacept.”
“The watchdog also rejected abatacept in that guidance.”
“But it also recommended adalimumab, etanercept, infliximab and abatacept for patients who have failed on one anti-TNF or who have not responded to other disease-modifying anti-rheumatic drugs, and who cannot take rituximab.”
“Nowadays, with aggressive treatment, including combinations of medications plus the new Biologic therapies (such as etanercept, adalimumab and abatacept), we are able to control the inflammation and prevent joint damage in the majority of patients.”
“Age - and sex-adjusted IRs of infections requiring hospitalization, including pneumonia (most frequent hospital infection), were used to estimate the expected IRs with abatacept by the method of indirect adjustment.”
“Rates for abatacept were similar to expected IRs based on other RA non-biologic DMARD cohorts.”
“Comparisons were made between the observed IRs in abatacept-treated patients and those in over 133,000 patients exposed to non-biologic DMARDs in 6 reference RA cohorts.”
“We pooled data from the cumulative abatacept RA clinical development program, both double-blind and open-label periods, to estimate the incidence rates (IRs) of infections requiring hospitalization including pneumonia and opportunistic infections, in comparison with RA patients treated with non-biologic DMARDs from several reference cohorts.”
“The safety of abatacept, including incidence of infections requiring hospitalization, will continue to be monitored in a post-marketing surveillance program.”
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