Definitions

from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. Any of various red, often toxic, polypeptide antibiotics obtained from soil bacteria.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any of a class of toxic polypeptide antibiotics found in soil bacteria of genus Streptomyces.

from the GNU version of the Collaborative International Dictionary of English

  • n. any of various red antibiotics isolated from soil bacteria with a three-ring heterocyclic nucleus with an attached peptide chain.

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • n. any of various red antibiotics isolated from soil bacteria

Etymologies

Sorry, no etymologies found.

Examples

  • An enormous molecule shaped like an ancient Greek statue, with a small, headless torso and two extended wings, actinomycin D was later found to work by binding and damaging DNA.

    The Emperor of All Maladies

  • Others, such as nitrogen mustard or actinomycin D, came from serendipitous sources, such as mustard gas or soil bacteria, found accidentally to kill cancer cells.

    The Emperor of All Maladies

  • In the summer of 1954, Farber persuaded Waksman to send him a number of antibiotics, including actinomycin D, to repurpose them as antitumor agents by testing the drugs on a series of mouse tumors.

    The Emperor of All Maladies

  • Farber found that actinomycin D, administered intravenously, potently inhibited the growth of these lung metastases, often producing remissions that lasted months.

    The Emperor of All Maladies

  • Within months, the team had confirmed that X-rays and actinomycin D were remarkably synergistic, each multiplying the toxic effect of the other.

    The Emperor of All Maladies

  • He has isolated, together with his students and associates, a number of new antibiotics, including actinomycin (1940), clavacin, streptothricin (1942), streptomycin (1943), grisein

    Selman A. Waksman - Biography

  • Cells were harvested at the indicated time points (hours after addition of actinomycin or vehicle or transfection with agRNA).

    Naturejobs - All Jobs

  • After 2 d, actinomycin D (act D, 1 μg ml − 1) or vehicle was added to the medium.

    Naturejobs - All Jobs

  • (Pol I) are polyadenylated and accumulate markedly after treatment with low concentrations of actinomycin D (ActD), which blocks the synthesis of full-length rRNA.

    Naturejobs - All Jobs

  • Overexpression of L11 or actinomycin D-induced ribosomal stress increases this L11-MDM2 interaction and subsequent p53 stabilization

    PLoS ONE Alerts: New Articles

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