Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A proteinaceous inclusion body that forms when cellular degradation machinery is impaired or overwhelmed

Etymologies

Sorry, no etymologies found.

Examples

  • Hideshima T, Bradner JE, Wong J, Chauhan D, Richardson P, et al. (2005) Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma.

    PLoS ONE Alerts: New Articles

  • In all cases analyzed, the inhibitor-induced pUL69 aggregates were clearly localized within viral replication centers but not subnuclear splicing, pore complex, or aggresome structures.

    Journal of Biological Chemistry current issue

  • Analogously, attachment of the ankyrin-like repeat to a huntingtin fragment lacking its aggresome-targeting signal promoted its transport to aggresomes.

    Journal of Biological Chemistry current issue

  • Furthermore, substitution of the ankyrin-like repeat in synphilin 1 with an aggresome-targeting signal from huntingtin was sufficient for aggresome formation upon inhibition of the proteasome.

    Journal of Biological Chemistry current issue

  • Abnormal polypeptides that escape proteasome-dependent degradation and aggregate in cytosol can be transported via microtubules to an aggresome, a recently discovered organelle where aggregated proteins are stored or degraded by autophagy.

    Journal of Biological Chemistry current issue

  • Importantly, translocation to aggresomes required a special aggresome-targeting signal within the sequence of synphilin 1, an ankyrin-like repeat domain.

    Journal of Biological Chemistry current issue

  • Therefore, aggresome formation, but not aggregation of synphilin

    Journal of Biological Chemistry current issue

  • However, proteasome or Hsp90 inhibition rapidly triggered their translocation into the aggresome, and surprisingly, this response was independent on the expression level of synphilin

    Journal of Biological Chemistry current issue

  • On the other hand, formation of multiple small aggregates required an entirely different segment within synphilin 1, indicating that aggregation and aggresome formation determinants can be separated genetically.

    Journal of Biological Chemistry current issue

Wordnik is becoming a not-for-profit! Read our announcement here.

Comments

Log in or sign up to get involved in the conversation. It's quick and easy.