from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Competitive struggle (especially political)
- n. The relationship between an agonist and a receptor
from the GNU version of the Collaborative International Dictionary of English
- n. Contention for a prize; a contest.
from The Century Dictionary and Cyclopedia
- n. Struggle or contest for a prize, especially at the ancient Grecian games.
- n. The prize itself.
Certainly this isn't always the case, but the tendency toward agonism and ad hominem attack in the responses of Eskelinen and others makes me worry that what begins as a distinction between different opinions can easily slip into counter-productive othering.
Well, OK, women can learn from men to take a certain amount of I sometimes call it agonism, you know, kind of ritual opposition talk, devil's advocate.
ANAVEX 2-73 is the first of a new class of compounds that act through sigma-1 receptor agonism as well as muscarinic cholinergic effects and modulation of endoplasmic reticulum stress thought to trigger a series of intracellular effects which modify ion channel signaling at the mitochondrial level.
GABA-B receptor (GABA-BR) agonism (activation) has been validated as a potentially effective treatment in a number of indications including pain and overactive bladder (OAB).
In fact, the agent was designed specifically to overcome deficiencies of available androgen-receptor antagonists, such as low binding affinity and partial agonism.
Other approaches try to combine PPAR alpha, gamma and delta agonism in one molecule and to find the right balance.
Delta agonism may address these issues with a unique mechanism of action, unlike current industry efforts to reformulate existing opioid therapeutics to address abuse concerns.
It's related to yohimbine, a compound which is often included in various fat loss formulas because of its ability to antagonize alpha 2-adrenoceptors, allowing lipolysis itself, while also allowing lipolysis to continue from beta adrenoceptor agonism as well (11,12).
ANAVEX 2-73 is the first of a new class of compounds which act through sigma-1 receptor agonism as well as muscarinic cholinergic effects and modulation of endoplasmic reticulum stress thought to trigger a series of intracellular effects which modify ion channel signaling at the mitochondrial level.
Validated and well-recognized, standard non-transgenic animal models were used to show statistically significant neuroprotective effects via both muscarinic cholinergic and sigma-1 receptor agonism effects.
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