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Examples
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IFN alpha-2a for hepatitis C. DSM has successfully started development, scale-up and manufacture of the recombinant his-tagged IFN alpha-2a.
THE MEDICAL NEWS 2010
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DSM, PolyTherics enter agreement for HiPEG IFN alpha-2a product development
THE MEDICAL NEWS 2010
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DSM, PolyTherics enter agreement for HiPEG IFN alpha-2a product development
THE MEDICAL NEWS 2010
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DSM, PolyTherics enter agreement for HiPEG IFN alpha-2a product development
THE MEDICAL NEWS 2010
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PolyTherics has applied its HiPEG ™ site-specific PEGylation technology to interferon alpha to produce a product (HiPEG ™ IFN alpha-2a) that has eight-fold higher activity than a marketed
THE MEDICAL NEWS 2010
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DSM, PolyTherics enter agreement for HiPEG IFN alpha-2a product development
THE MEDICAL NEWS 2010
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PolyTherics has applied its HiPEG (TM) site-specific PEGylation technology to interferon alpha to produce a product (HiPEG (TM) IFN alpha-2a) that has eight-fold higher activity than a marketed PEGylated interferon in vitro and a comparable half-life in a preclinical study.
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The data to be presented are from the GI-5005-02 trial in patients with chronic HCV infection comparing treatment with GI-5005 plus peginterferon alpha-2a/ribavirin versus peginterferon alfa-2a/ribavirin alone and include sustained virologic response (SVR) rates for subjects who have not been previously treated with an interferon based regimen.
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The companies intend to develop a robust process to produce sufficient material for preclinical development and then for cGMP production of HiPEG (TM) IFN alpha-2a for clinical development.
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DSM, PolyTherics enter agreement for HiPEG IFN alpha-2a product development
THE MEDICAL NEWS 2010
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