American Heritage® Dictionary of the English Language, Fourth Edition
- n. The stage of mitosis and meiosis in which the chromosomes move to opposite ends of the nuclear spindle.
Century Dictionary and Cyclopedia
- n. In cytology, a stage in mitosis, or karyokineticcell-division, characterized by the moving apart of the chromosomes destined to enter the two daughter-nuclei.
- n. cytology the stage of mitosis and meiosis during which the chromosomes separate; the chromatid moving to opposite poles of the cell
GNU Webster's 1913
- n. the stage of meiosis or mitosis when chromosomes move toward opposite ends of the nuclear spindle.
- n. the stage of meiosis or mitosis when chromosomes move toward opposite ends of the nuclear spindle
“Seldom has the word "anaphase" held more suppressed longing.”
“In the current study, the investigators found that when cancer cells with extra centrosomes enter "anaphase" - the stage of cell division when chromosomes move toward the poles of the spindle before being drawn into the new daughter cells - a few chromosomes lagged behind the others.”
“The metaphase-anaphase transition is orchestrated through proteolysis of numerous proteins by a ubiquitin protein ligase called the anaphase-promoting complex or cyclosome (APC/C).”
“It also reported that inhibition of CDK2 by seliciclib suppressed lung cancer growth both in vitro and in vivo of lung cancer cells addicted to CDK2/cyclin E; and lung cancer cells underwent apoptosis or cell suicide by induction of a novel mechanism called anaphase catastrophe, as illustrated in the journal's front cover.”
“This resulted in the identification of two ubiquitin-protein ligase complexes: the cyclosome, now also called anaphase-promoting complex or APC / C, involved in the degradation of mitotic cyclins and some other cell cycle regulatory proteins in exit from mitosis”
“The E3 enzyme responsible, a protein complex termed the "anaphase-promoting complex" (APC) checks that the cell goes out of mitosis.”
“A rise in intracellular calcium at the onset of anaphase could regulate the polar ejection force by shutting down the centriolar turbines, but defective regulation could result in an excessive force that contributes to the chromosomal instability characteristic of most cancer cells.”
“In contrast, 82.5% of injected cells align chromosomes in metaphase, progress to anaphase, and display chromosome velocities not significantly different from control cells.”
“It should be possible to test this by observing chromosome behavior in the spindles of dividing animal cells while artificially raising the concentration of intracellular calcium during prometaphase or blocking its rise at the beginning of anaphase.”
“But today I could barely talk, coughing up reams of horrifying crap, and even writing this sentence is taking all the late-anaphase mitosis I can muster.”
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