from The American Heritage® Dictionary of the English Language, 4th Edition
- adj. Having a chromosome number that is not a multiple of the haploid number for the species.
- n. A cell or an organism characterized by an aneuploid chromosome number.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- adj. Having a number of chromosomes that is not a multiple of the haploid number.
- n. A cell or an organism having such a number of chromosomes.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- adj. having a chromosome number that is not an exact multiple of the haploid number
Sorry, no etymologies found.
Such results can be related to the formation of meiotic trivalent in the hybrids leading to the production of viable aneuploid gametes and post-zygotic elimination of embryos due to chromosomal non disjunction events at meiosis.
Feeding of freshly irradiated wheat resulted in significantly increased incidence of polyploid cells in bone marrow, aneuploid cells in testis, reduction in number of spermatogonia of types A, B and resting primary spermatocytes as well as a higher mutagenic index.
However, some leukemias and lymphomas are not aneuploid, and dysregulated expression of multiple genes is likely to be the main reason why aneuploidy is a marker for cells with abnormal phenotypes.
In other words, more aneuploid embryos are formed than ever show up as pregnancies, and more pregnancies with aneuploid embryos spontaneously terminate at some early stage than ever continue to term.
If the blastomere is aneuploid, this molecular tool, called "fluorescence in situ hybridization," or FISH, will unmask it.
According to Dr. Jan Ellenberg of the European Molecular Biology Laboratory EMBL who led the study, aneuploid embryos do not usually survive to term.
"The reason for aneuploid embryos are mostly aneuploid oocytes immature egg cells, as aneuploid sperm are relatively rare with an estimated frequency of about 2 per cent, while aneuploid oocytes are quite common with an estimated frequency of more than 20 per cent," he says.
The rate of aneuploid fetuses averaged over all stages of prenatal development and all ages of the mothers is around five per cent.
Under the new model, a series of hypotheses tests are formulated to explain the pattern of the genetic control of cancer through aneuploid loci.
Birchler JA, Newton KJ (1981) Modulation of protein levels in chromosomal dosage series of maize: The biochemical basis of aneuploid syndromes.
Wordnik is becoming a not-for-profit! Read our announcement here.