from The American Heritage® Dictionary of the English Language, 4th Edition
- n. A naturally occurring protein that is a specific inhibitor of endothelial proliferation and a potent angiogenesis inhibitor. It is under investigation as a potential cancer therapy.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A protein that inhibits angiogenesis; it is used to inhibit the growth of new blood vessels in tumours
They are called angiostatin receptor blockers and they are given to heart failure patients, to blood pressure patients.
The angiostatin trials, taking place at Thomas Jefferson University Hospital in Philadelphia, are still getting underway.
At least 20 drugs called angiogenesis inhibitors are now in clinical trials, including angiostatin and endostatin, the compounds isolated by Dr. Michael O'Reilly in Folkman's lab.
AMOTL2 belongs to the angiomotin family which mediates inhibition of endothelial cell migration and tube formation by binding to angiostatin
The popularity of the idea waned in the early 2000s following disappointing results in clinical trials of two anti-angiogenic compounds, angiostatin and endostatin, that were discovered in Folkman's lab.
Some bio - therapeutic treatments include gene therapy, to replace or repair damaged genes or to boost the immune system; Angiogenesis inhibitors like angiostatin and endostatin, that cut off the blood supply to tumors, depriving them of the nourishment they need to grow; antisense therapy that blocks the formation of important proteins that keep cancer cells from growing and spreading; and monoclonal antibodies, biological smart bombs that target select portions of cancer cells, leaving healthy tissue alone.
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