“ Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, et al. Molecular basis of human hypertension: role of angiotensinogen.”
“This resulted in proportionally higher levels of gene products (i.e. plasma angiotensinogen protein) and, importantly, proportionally higher blood pressure with increasing gene copy number.”
“In spite of the discovery that angiotensinogen (AGT) gene polymorphism is associated with essential hypertension, the genetics of this disease has remained poorly understood .”
“And the risk is heightened by two other compounds produced in fat cells: plasminogen activator inhibitor-1, which blocks the body's own clot-busters, and angiotensinogen, which leads to high blood pressure.”
“Conversely, captopril treatment decreased expression of AT1R and angiotensinogen.”
“A team led by Aiwu Zhou at the Cambridge Institute for Medical Research used intense x-ray beams at the angiotensinogen, a protein linked to high blood pressure.”
“Zhou's team found that angiotensinogen changes shape when it is oxidised by reactive molecules in the blood.”
“They showed that in healthy people, a steady 60% of angiotensinogen was oxidised, but in women with pre-eclampsia the level was much higher.”
“Professor Carrell said changes in the placenta during pregnancy alter how much oxygen the growing baby receives, but this can trigger the release of free radicals that oxidise angiotensinogen and cause blood pressure to rise.”
“University reported in the journal Nature that women with pre-eclampsia have high blood levels of a certain protein called angiotensinogen.”
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