American Heritage® Dictionary of the English Language, Fourth Edition
- n. A natural polypeptide and protease inhibitor that affects blood clotting and is used during high-risk surgery, such as cardiopulmonary bypass, to reduce bleeding.
- a-1 + prot(e)in(ase) + -in. (American Heritage® Dictionary of the English Language, Fourth Edition)
“From Ottawa - With a study showing that Trasylol, also known as aprotinin, raises the risk of death following heart surgery by 50%, Bayer has suspended further manufacturing and marketing of the compound.”
“Trasylol, also known as aprotinin, raises the risk of death following heart surgery by 50%,”
“Contrary to recent studies, proper use of a drug called aprotinin to reduce bleeding during heart su ...”
“Based on its initial review, "Bayer believes that the results of this study should not serve as a basis for affecting the use of aprotinin ...”
“Patients who got aprotinin were about 50% more likely to die in the five years after surgery than patients who received no drug.”
“More than 4 million patients worldwide have received aprotinin, sold as Trasylol, since 1985, the scientists write in the Journal of the American Medical Association.”
“An accompanying editorial says "in all likelihood, this is the end of the aprotinin story.”
“The study found that 6% of patients who received Trasylol, or aprotinin, died within 30 days of surgery compared to 4% of patients who received tranexamic acid or aminocaproic acid.”
“Of the 108 patients who died, the proportion with "cardiogenic shock, right ventricular failure, congestive heart failure, or myocardial infarction was higher in the aprotinin group than in the other two groups," the study said.”
“The new study published in the January 26, 2006 New England Journal of Medicine (NEJM), found patients who received Trasylol (aprotinin) have experienced potentially deadly side effects including:”
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