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However, most Mediator targets identified in the genome-wide analysis are false positives that arose for several interrelated reasons: the use of overly lenient cut-offs; artifactual differences in apparent IP efficiencies among different genomic regions in the untagged strain; low fold-enrichments making it difficult to distinguish true Mediator targets from false positives that occur in the absence of the tagged Mediator protein.— PLoS ONE Alerts: New Articles
However, this approach also identifies "false positive" genomic regions that preferentially appear in the IP sample due to artifactual association with the agarose beads and / or the antibody (or something in the antibody preparation).— PLoS ONE Alerts: New Articles
Such artifactual interactions can give rise to reproducible 2-fold enrichments of some genomic regions over others— PLoS ONE Alerts: New Articles
Second, most Mediator targets identified by Andrau et al [11] are false positives that arose for several interrelated reasons: the use of overly lenient cut-offs; artifactual differences in apparent IP efficiencies among different genomic regions in the untagged strain; low fold-enrichments making it difficult to distinguish true Mediator targets from false positives that occur in the absence of a tagged Mediator protein.— PLoS ONE Alerts: New Articles
Virtual Reality: An artifactual environment, image, process or scenario conjured and experienced through sensory or neuronal stimuli and in which one's actions partially determine what happens in the environment.— Science News / Features, Blog Entries, Column Entries, Issues, News Items and Book Reviews

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