atovaquone

For instance, in the case of atovaquone, a clinical study showed that about one in a trillion cells had spontaneous resistance.

Behe Responds 2007

These include chloroquine, mefloquine (Lariam), atovaquone-proguanil (Malarone), quinine, and doxycycline artemisin derivatives, which are not licensed for use in the United States but are often found overseas.

Malaria 2008

Common antimalarial drugs include atovaquone/proguanil, doxycycline and mefloquine.

4 Ways to Survive Malaria-risk Destinations 2008

Mutations in Plasmodium falciparum, cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site.

The Edge of Evolution Michael J. Behe 2007

Resistance to a second drug atovaquone was about one in a hundred thousand.

The Edge of Evolution Michael J. Behe 2007

Frequency of drug resistance in Plasmodium falciparum: a nonsynergistic combination of 5-fluoroorotate and atovaquone suppresses in vitro resistance.

The Edge of Evolution Michael J. Behe 2007

A relatively new drug, atovaquone, which interfered with a different step in P. falciparum metabolism, can be countered by a single amino acid mutation in a protein called cytochrome b.3 The very latest drug, artemisinin, is derived from the Chinese sweet wormwood plant.

The Edge of Evolution Michael J. Behe 2007

Spontaneous resistance to atovaquone can be found in roughly every third sick person.17 Spontaneous resistance to chloroquine can be found perhaps in every billionth sick person, and since there are usually close to a billion sick people on the planet every year or so, that means chloroquine resistance is usually waiting to be found in at least one person, somewhere in the world, at any given time.

The Edge of Evolution Michael J. Behe 2007

Resistance to one recent drug, atovaquone, arose in the lab scant weeks after a small culture of malaria was exposed to it.

The Edge of Evolution Michael J. Behe 2007

For instance, in the case of atovaquone, a clinical study showed that about one in a trillion cells had spontaneous resistance.15 In another experiment it was shown that a single amino acid mutation, causing a change at position number 268 in a single protein, was enough to make P. falciparum resistant to the drug.

The Edge of Evolution Michael J. Behe 2007