Did you perchance mean attractive?
- adj. immunology, medicine Acting against the organism by which it was produced
- auto- + reactive (Wiktionary)
“So-called autoreactive T cells, which recognize the body's own structures, must be eradicated or pacified to avoid that they can cause harm.”
“Regulatory T cells appear to alter the chemical environment around their aggressive cousins, known as autoreactive T cells, in ways that either suppress them or cause them to proliferate, the study found.”
“Using human cell lines and isolated mouse cells, Dr. Petar Lenert, an assistant professor of internal medicine at the University of Iowa, said he and his colleagues showed the DNA-like compounds were able to selectively reduce the activity of two types of immune cells called autoreactive B cells and dendritic cells.”
“Luckily, the same defect that allows autoreactive T cells to escape from the bone marrow also results in a flaw on the surface of these T cells that allows them to be singled out and destroyed.”
“In every experiment a significant proportion—slightly less than half of the mice in these three studies—were cured, suggesting that even severely diabetic mice who have experienced significant damage to the pancreas over time still have the capacity to regenerate new beta cells if the autoreactive T cells can be eliminated.”
“But many T cells are “born” faulty when they are first produced in the bone marrow; they mistakenly react to the body itself, rather than to outside pathogens: they are “autoreactive.””
“In normal circumstances 99 percent or more of these friendly-fire-prone T cells are killed off quite efficiently; the body recognizes them as autoreactive—long before they escape out of the bone marrow—because they have a protein sequence on their surfaces different from the good kind of T cells that help to defend us from invading foes.”
“The fact that Faustman was able to uncover and identify this specific group of flawed autoreactive T cells escaping out of the bone marrow was hugely promising.”
“Immunologists thereafter devoted 30 years discovering ways by which autoreactive lymphocyte clones can be deleted and why they fail to be deleted in autoimmune patients ¦.”
“By this time, immunology had laid its foundation on the clonal selection theory, which forbids autoreactive clones in normal individuals.”
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