from The American Heritage® Dictionary of the English Language, 4th Edition
- n. An alkylating agent, C6H14O6S2, that is used as an antineoplastic drug in the treatment of chronic myelocytic leukemia.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A particular drug used in chemotherapy.
General, was dealing with a shortage of busulfan, a drug used in bone marrow transplantation.
While life-saving in many cases, radiotherapy and chemotherapy with alkylating agents, such as busulfan, cyclophosphamide and dacarbazine, can damage DNA.
In children, GSTM1 polymorphism seems to modify BU pharmacokinetics after intravenous drug administration. busulfan, hematopoietic stem cell transplantation, glutathione
Methods We infused autologous CD34+ bone marrow cells transduced with a retroviral vector containing the ADA gene into 10 children with SCID due to ADA deficiency who lacked an HLA-identical sibling donor, after nonmyeloablative conditioning with busulfan.
After transfection of the cells with the gene, the cells are re-infused back into the patients after nonmyeloablative conditioning with busulfan.
III) - based metal-organic frameworks with engineered cores and surfaces, as well as imaging properties, function as superior nanocarriers for efficient controlled delivery of challenging antitumoural and retroviral drugs (that is, busulfan, azidothymidine triphosphate, doxorubicin or cidofovir) against cancer and AIDS.
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