Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any of a class of transmembrane proteins important in maintaining tissue structure.

Etymologies

From calcium-dependent adhesion molecules and -in. (Wiktionary)

Examples

  • E-cadherin is probably the best understood cadherin.

    Cadherins, Part 1

  • For example, if a certain kind of protein on the surface of a cell - a "cadherin" -- tends to get sticky under certain microenvironmental conditions, and when this happens cadherin-bearing cells will clump together.

    The Origin of Form Was Abrupt Not Gradual

  • The studies identified variants located in a region of the chromosome between two genes encoding cell adhesion molecules called cadherin 9 and cadherin 10.

    Science News / Features, Blog Entries, Column Entries, Issues, News Items and Book Reviews

  • Downregulation of E-cadherin (CDH1) and upregulation of N-cadherin (CDH2) - the so called cadherin-switch - were most evident in EPT1 cells.

    PLoS ONE Alerts: New Articles

  • Blaschuk, OW, et al. E-cadherin, estrogens and cancer: is there a connection?

    T.S. Wiley: Estrogen Dilemma: There Is No Dilemma When You Know the Details

  • Likewise, choanoflagellates have five immunoglobulin domains, though they have no immune system; collagen, integrin and cadherin domains, though they have no skeleton or matrix binding cells together; and proteins called tyrosine kinases that are a key part of signaling between cells, even though Monosiga is not known to communicate, or at least does not form colonies.

    An Animal Toolkit in a Single-Celled Organism

  • "Choanoflagellates show no hint of multicellularity, but they have 23 genes for cadherin proteins, about the same as the fruit fly or the mouse."

    An Animal Toolkit in a Single-Celled Organism

  • It consists of 5 cadherin repeats (EC1 ~ EC5) in the extracellular domain, one transmembrane domain, and an intracellular domain that binds p120-catenin and beta-catenin.

    Cadherins, Part 1

  • In epithelial cells, E-cadherin-containing cell-to-cell junctions are often adjacent to actin-containing filaments of the cytoskeleton. janeashley

    Cadherins, Part 1

  • The intracellular domain contains a highly-phosphorylated region vital to beta-catenin binding and therefore to E-cadherin function.

    Cadherins, Part 1

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