Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A protein (with a corresponding gene of the same name) that is an endogenous calpain inhibitor

Etymologies

Sorry, no etymologies found.

Examples

  • Furthermore, the researchers discovered how calpastatin evades being chewed up by calpain.

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  • "However, there was no overall picture of calpastatin that revealed how it was so precise in its attachment and potent in its function."

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  • "This new structural information on calpastatin and on calpain's conformational changes not only explains a lot about calpain's regulation," Green said.

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  • "Calpain has multiple domains, and what we saw was that calpastatin wraps itself around pretty much every domain of calpain," said Moldoveanu, the report's first author.

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  • This broad embrace also guarantees that calpastatin will precisely recognize only calpains, rather than mistakenly attach to other similar enzymes in the cell.

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  • The structural picture obtained of the two proteins clutched together clearly revealed why calpastatin so specifically attaches to calpain.

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  • Nature, Green and his colleagues report new information on the specificity of calpastatin.

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  • "Previous studies on calpastatin had revealed how a few of the parts of the calpastatin molecule attach to calpain in the inhibition process," said Green, the report's senior author.

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  • A central question has been how calpastatin is so exquisitely specific in attaching to calpain and inhibiting it-essentially ignoring other highly similar enzymes in the cell.

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  • However, such a critical enzyme needs ultra-precise control, which is the job of another protein called calpastatin.

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