GNU Webster's 1913
- n. (Chem.) An alkaloidal principle obtained from the celandine, and named from the red color of its salts. It is a colorless crystalline substance, and acts as an acrid narcotic poison. It is identical with
- Ancient Greek celandine + red. (Wiktionary)
“It is paramount to note that this similarity in chelerythrine binding between the two proteins would have not been discovered if it was not for the identification of the initial conserved ligand binding site between PrgI and Bcl-xL using the FAST-NMR method in combination with the CPASS database.”
“This issue may be minimized or eliminated by simply improving the PrgI binding affinity for chelerythrine derivatives.”
“Two compounds, chelerythrine and sanquinarine were identified as having affinity to Bcl-xL and were both available from commercial suppliers.”
“A comparison between the free and chelerythrine bound PrgI 2D”
“The didecyldimethylammonium bromide binding site (A) is found in a region responsible for needle formation while the chelerythrine binding site (B) is found on the opposite face. doi: 10.1371/journal. pone.0007442.g004”
“The initial identification of the conserved DDAB ligand binding site between Bcl-xL and PrgI was used to predict, test and confirm that chelerythrine binds PrgI in a similar manner to Bcl-xL.”
“This active-site similarity was then used to verify that chelerythrine, a known Bcl-xL inhibitor, also binds PrgI.”
“Verification that the Bcl-xL inhibitor chelerythrine also binds PrgI.”
“(C) The Bcl-xL region shown to bind chelerythrine is highlighted while the remaining protein structure is transparent.”
“(blue) illustrating the structural similarity of the chelerythrine binding sites.”
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