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chemoresistance

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. The resistance of a cell to the actions of a chemical compound
  • n. The resistance of a tumour to chemotherapy

Etymologies

chemo- +‎ resistance (Wiktionary)

Examples

  • Oncolytic viruses and DNA-repair machinery: overcoming chemoresistance of gliomas.

    I don't even know where to start with this one . . . - The Panda's Thumb

  • PDCD4, a direct target gene of miR-21, could mediate chemoresistance to docetaxel in PC3 cells.

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  • To investigate whether microRNA-21 was involved in mediating the chemoresistance of prostate cancer cells to docetaxel.

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  • AM, Watson IR, Evans AJ, Foster DA, Irwin MS, et al. (2009) Suppression of hypoxia-inducible factor 2alpha restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cells.

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  • Sun L, Zhang H, Shi Y, et al. (2008) Hypoxia-inducible factor-1 alpha contributes to hypoxia-induced chemoresistance in gastric cancer.

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  • Different from our observation, recent work on chemoresistance towards etoposide in HIF-1α-deficient immortalized murine embryonic fibroblasts did not observe an induction of p21

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  • Cusack JC Jr, Liu R, Baldwin AS Jr (1999) Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB.

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  • The transcription factor HIF-1α has been established as important mediator of hypoxia-mediated chemoresistance

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  • Interestingly, a recent study from Japan demonstrated lower efficacy of 5-FU-based chemotherapy in HIF-1α-expressing human gastric adenocarcinomas, strengthening the perception of HIF-1 as a pivotal factor in the determination of gastric cancer chemoresistance

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  • Well in line with our results, both studies concluded a pivotal role for HIF-1α in mediating chemoresistance under normoxic conditions.

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