Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any protein that binds to an activator as part of gene transcription

Etymologies

Sorry, no etymologies found.

Examples

  • In contrast, FGF-19 increased the activity of STAT3, an inhibitor of SREBP-1c expression and decreased the expression coactivator-1β (PGC-1β), an activator of SREBP-1c activity.

    Journal of Biological Chemistry current issue

  • When mice that lack steroid receptor-2 (SRC-2) - a master regulator gene called a coactivator

    Health News from Medical News Today

  • Like, what regulates the SRC-3 coactivator, plus two other ones?

    A Dubious "Opportunity" for IDers

  • Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump.

    Fat is Not Your Fate

  • Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, et al. (2001) Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function.

    PLoS ONE Alerts: New Articles

  • "At the membrane, the enzyme PAK1 (p21-activted kinase 1) phosphorylates (attaches a phosphate molecule that activates the coactivator) SRC-3, allowing it to function at the membrane," said O'Malley, responsible for identifying the first receptor coactivator and advancing the field in general.

    RedOrbit News - Technology

  • The master gene called SRC-3 (steroid receptor coactivator 3) not only enhances estrogen-dependent growth of cancer cells by activating and encouraging the transcription of a genetic message into a protein, it also sends a signal to the cell membrane to promote cell motility or movement - a key element of cancer spread or metastasis, said Baylor College of Medicine researchers and collaborators in a report that appears in the current issue of the journal

    Medlogs - Recent stories

  • The master gene called SRC-3 (steroid receptor coactivator 3) not only enhances estrogen-dependent g ...

    THE MEDICAL NEWS

  • A muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolism, Wei Chen, Xiaoting Zhang, Kivanc Birsoy and Robert G. Roeder

    PhysOrg.com - latest science and technology news stories

  • The researchers, led by Wei Chen, a research associate in the Laboratory of Biochemistry and Molecular Biology, focused on a protein called MED1, which makes up part of a gene regulating machine called the Mediator coactivator complex.

    PhysOrg.com - latest science and technology news stories

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