“In contrast, FGF-19 increased the activity of STAT3, an inhibitor of SREBP-1c expression and decreased the expression coactivator-1β (PGC-1β), an activator of SREBP-1c activity.”
“When mice that lack steroid receptor-2 (SRC-2) - a master regulator gene called a coactivator”
“Like, what regulates the SRC-3 coactivator, plus two other ones?”
“Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump.”
“Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, et al. (2001) Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function.”
“At the membrane, the enzyme PAK1 (p21-activted kinase 1) phosphorylates (attaches a phosphate molecule that activates the coactivator) SRC-3, allowing it to function at the membrane," said O'Malley, responsible for identifying the first receptor coactivator and advancing the field in general.”
“The master gene called SRC-3 (steroid receptor coactivator 3) not only enhances estrogen-dependent growth of cancer cells by activating and encouraging the transcription of a genetic message into a protein, it also sends a signal to the cell membrane to promote cell motility or movement - a key element of cancer spread or metastasis, said Baylor College of Medicine researchers and collaborators in a report that appears in the current issue of the journal”
“The master gene called SRC-3 (steroid receptor coactivator 3) not only enhances estrogen-dependent g ...”
“A muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolism, Wei Chen, Xiaoting Zhang, Kivanc Birsoy and Robert G. Roeder”
“The researchers, led by Wei Chen, a research associate in the Laboratory of Biochemistry and Molecular Biology, focused on a protein called MED1, which makes up part of a gene regulating machine called the Mediator coactivator complex.”
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