Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A soluble seven-protein complex which is a precursor of coat protein I (COPI), which plays a key role in Golgi apparatus vesicle formation

Etymologies

Coined in a 1991 paper in Nature by Waters, Serafini & Rothman. (Wiktionary)

Examples

  • A second motif proximal to the cNLS is a cluster of arginines that serves coatomer-mediated retrieval of SUN2 from the Golgi.

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  • Michelsen K, Schmid V, Metz J, Heusser K, Liebel U, et al. (2007) Novel cargo-binding site in the {beta} and {delta} subunits of coatomer.

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  • These lysines have been shown to form part of an interaction site with coatomer protein I (COP-I) [10], [13], [14].

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  • The minimal machinery necessary to form these retrograde transport vesicles has been shown to be only two proteins; coatomer protein and

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  • The di-arginine motif has also been shown to directly bind to the coatomer complex.

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  • Further evidence of the di-arginine motif binding to coatomer protein was provided more recently by key mutations made to the α and β subunit of COP I, which although led to the formation of the coatomer complex had lost its ability to bind to the di-lysine motif

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  • Pavel J, Coccia F, Draken E, Wegehingel S, et al. (1996) Nonclathrin coat protein gamma, a subunit of coatomer, binds to the cytoplasmic dilysine motif of membrane proteins of the early secretory pathway.

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  • Sec28p was also found in vesicles adjacent to the vacuolar membrane in the ret2-1 coatomer mutant.

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  • Furthermore, Vid24p association with Vid vesicles was impaired when coatomer genes were mutated.

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  • When SEC28 and other coatomer genes were mutated, FBPase degradation was defective and FBPase association with Vid vesicles was impaired.

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