conine

The formula of conine, C_ {8} H_ {17} N, shows it to be homologous with piperidine, C_ {5} H_ {11} N, a derivative of piperine, the alkaloid of pepper, to be spoken of later; and, just as piperidine is derived from pyridine by the action of reducing agents, so conine is probably derived from a propyl-pyridine.

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But with this granted, the simplest alkaloid formulas, those of conine, C_ {8} H_ {17} N, and nicotine,

Scientific American Supplement, No. 415, December 15, 1883 Various

Taking up the volatile alkaloids, we find with regard to _conine_, first, that the action of methyl iodide shows it to be a secondary amine, that is, it restrains only one replaceable hydrogen atom of the original ammonia molecule.

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Prof. Filehne, of Erlangen, who has studied a large number of these pyridine and quinoline derivatives, found, moreover, that the hydrochlorate of ethyl-piperidine had a physiological action quite analogous to that of conine.

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Piperidine, the decomposition product of piperine, which we have shown may be considered to be hexahydropyridine, was examined by Dr. Kronecker, of Berlin, at the request of Prof. Hofmann, and was found to have an action upon animals in many respects resembling that of conine.

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From conine can be prepared methyl-conine, which also occurs in nature, and dimethyl-conine.

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If a volatile alkaloid, add a few pieces of calcium chloride to ethereal solution to absorb the water; draw off the ethereal solution with a pipette, allow it to evaporate, and test the residue for the alkaloids, conine and nicotine.

Aids to Forensic Medicine and Toxicology

I had in front of me some of the finest destructive agents you could wish to light upon -- carbon-monoxide, chlorine-trioxide, mercuric-oxide, conine, potassamide, potassium-carboxide, cyanogen -- when Edwards entered.

The Beetle Richard Marsh

The artificial alkaloid paraconine, isomeric with the natural conine, will be referred to later.

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Tropine, when heated to 180°C. with concentrated hydrochloric acid, splits off a molecule of water, and yields tropidine, C_ {8} H_ {13} N, a liquid base, with an odor resembling conine.

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