curarine

Definitions

n. An alkaloid extracted from curari, forming colorless prisms more poisonous than the curari which yields it. One hundredth of a gram introduced into the skin of a rabbit produces death in a short time.

n. (Chem.) A deadly alkaloid extracted from the curare poison and from the Strychnos toxifera. It is obtained in crystalline colorless salts.

“Unlike the response of the denervated muscle to acetylcholine, this quick response of normal mammalian muscle is suppressed with great ease by curarine.”

Sir Henry Dale - Nobel Lecture
“If, on the other hand, the muscle was completely paralysed to the effects of nerve impulses by curarine, stimulation of its motor nerve fibres caused the usual output of acerylcholine, though the muscle remained completely passive.”

Sir Henry Dale - Nobel Lecture
“They showed, further, that the ganglion cells might be paralysed by nicotine or curarine, so that they would no longer respond to preganglionic stimulation or to the injection of acetylcholine, but that such treatment did not, in the least, diminish the output of acetylcholine caused by the arrival of preganglionic impulses at the synapses.”

Sir Henry Dale - Nobel Lecture
“Doctor, are you acquainted with the poison known as curari or curarine?”

The Lost Despatch
“The poisonous properties of the plant reside in two alkaloids isolated by Lukowsky from the leaves: _oleandrine_, extremely toxic and _pseudo-curarine_, as its name indicates, resembling curare in its action.”

The Medicinal Plants of the Philippines
“I found some substance remaining in it; made several tests, and discovered that it was a solution of curari or curarine. ”

The Lost Despatch