from The American Heritage® Dictionary of the English Language, 4th Edition
- n. The dissolution or destruction of a cell.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. The pathological breakdown of a cell due to the bursting of the cell membrane caused by osmosis.
from The Century Dictionary and Cyclopedia
- n. In pathology, the destruction or degeneration of cells.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. pathological breakdown of cells by the destruction of their outer membrane
Sorry, no etymologies found.
The strong cytotoxic activity of our UCB-derived NK cells against various tumor cell lines as well as the cytolysis of primary AML cells were displayed by specific lysis, CD107a-mediated degranulation and the production of IFNγ.
Functional analysis showed that these ex vivo-generated NK cells efficiently target myeloid leukemia and melanoma tumor cell lines, and mediate cytolysis of primary leukemia cells at low NK-target ratios.
The Ruhl method involved enzymatic dissociation of myenteric plexus samples, the purification of enteric glial cells via complement-mediated cytolysis of contaminating cells, and transformation by retroviral gene transfer.
The group followed-up the patients for 20 months observing that although serum aminotransferases did not normalize in either group, telmisartan reduced cytolysis by 30. 28\% and improved insulin resistance by 42. 63\% consequently with a significant decrease of NAS and fibrosis scores and an amelioration of the lipid profile.
Conversely, despite a significant reduction of cytolysis levels by 23. 22\% and of IR by 21. 4\%, valsartan did not improved liver histology (except steatosis) and had no effect on plasma lipids.
They compared the efficacy of telmisartan vs valsartan in a randomized double blind pilot trial assessing insulin resistance, cytolysis and NASH activity score (NAS) in 54 patients with NASH and mild-to moderate hypertension.
By observing in clinical conditions significant reduction of insulin resistance by both ARBs, as well as a moderate decrease of cytolysis, the study confirms that ARBs not only can correct hypertension, but also can act by preventing and treating steatohepatitis as an end-organ effect of metabolic syndrome.
This is one of the first human blinded trials evaluating the effects of telmisartan and valsartan in steatohepatitis that uses paired liver biopsies with NAS evaluation, simultaneously with cytolysis, insulin resistance, and lipid profile assessment.
The primary endpoints of the study were to prove that ARBs can ameliorate insulin resistance in mild-to-moderate hypertensive patients with histologically confirmed NASH, showing that monotherapy with ARBs on a regularly base can ameliorate cytolysis and NAS, while the secondary endpoint was to prove certain superiority of telmisartan vs valsartan probably linked to its specific insulin sensitizing action releated to the peroxisome proliferator activated receptor (PPAR) gamma - modulatory effects.
The group followed-up the patients for 20 months observing that although serum aminotransferases did not normalized in either group, telmisartan reduced cytolysis by 30. 28\% and improved insulin resistance by 42. 63\% consequently with a significant decrease of NAS and fibrosis scores and an amelioration of the lipid profile.
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