from The American Heritage® Dictionary of the English Language, 4th Edition
- n. A nucleotide containing deoxyribose that is a constituent of DNA.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. (genetics) Any nucleotide containing deoxyribose
from the GNU version of the Collaborative International Dictionary of English
- n. an organic molecule consisting of a hereocyclic base attached to the 1-carbon of a deoxyribose ring, with a phosphate group esterified at the 5 position of the deoxyribose. Deoxyribonuceotides are the monomer units which make up deoxyribonucleic acid, the molecule carrying the hereditary information in most organisms. The most common forms of deoxyribonuceotide are thymidine-5′-phosphate (abbreviated TMP), deoxyadenosine-5′-phosphate (abbreviated dAMP), deoxyguanosine-5′-phosphate (abbreviated dGMP), and deoxycytidine-5′-phosphate (abbreviated dCMP).
They provide electrons for deoxyribonucleotide synthesis, function as antioxidant defenses, in detoxification, Fe/S biogenesis and participate in a variety of cellular processes.
Ribonucleotide reductase (RNR) catalyzes the rate-limiting step in deoxyribonucleotide synthesis essential for DNA replication and repair.
Folate deficiency decreases thymidylate synthesis from deoxyuridylate, which results in an imbalance of deoxyribonucleotide that may lead to excessive uracil misincorporation (UrMis) into
PCR reaction mixtures (50 µl) generally contained sterile molecular-grade water, 1x reaction buffer, 1.5 mM magnesium chloride, 1.25 U (0.25 µl) Go Taq polymerase (Promega, UK), 0.25 mM deoxyribonucleotide triphosphate (dNTPs), and 50 pmol of each primer.
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