desmosomes

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Most of the mutations that cause ARVC are in genes encoding components of a type of cell junctions called "desmosomes," which are particularly abundant in tissues that experience great mechanical force, such as the heart.

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Examples (6)

  • "ARVC has been linked to genetic mutations in proteins that form desmosomes, subcellular structures responsible for cell-to-cell adhesion," explains Saffitz, whose laboratory studies connections between cells in the heart and their relationship to arrhythmias and sudden cardiac death. —  PhysOrg.com - latest science and technology news stories
  • Most of the mutations that cause ARVC are in genes encoding components of a type of cell junctions called "desmosomes," which are particularly abundant in tissues that experience great mechanical force, such as the heart. —  The Harvard Crimson :: News
  • The dynamic formation and dissolution of cell-cell junctional complexes is a central process during EMT Using Agilent Whole Human Genome Microarray data, we compared the expression patterns of genes involved in adherens junctions, tight junctions and desmosomes between EP156T cells and EPT1 cells. —  PLoS ONE Alerts: New Articles
  • The gene expression of entire modules of cell junctions such as adherens junctions, gap junctions, tight junctions, desmosomes and hemidesmosomes were downregulated almost simultaneously as EPT1 arose from EP156T cells. —  PLoS ONE Alerts: New Articles
  • Cell junctions, especially adherens junctions, tight junctions and desmosomes, are required for the epithelial phenotype and keeping neighbouring epithelial cells strongly attached to each other —  PLoS ONE Alerts: New Articles
 

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