Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A glycoside, obtained from Digitalis purpurea, that is used as a detergent and whose aglycone is digitogenin.

from The Century Dictionary and Cyclopedia

  • n. A colorless levorotatory glucoside, C27H46O145H2O, found in commercial digitalin. It crystallizes in slender needles which soften and turn yellow at 235° C.

Etymologies

Sorry, no etymologies found.

Examples

  • To probe for such effects, we tested the green tea compound epigallocatechin gallate (EGCG) and the membrane permeabilising digitonin on

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  • Only after more than 10 h an effect of these digitonin concentrations was detected.

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  • Using the membrane permeabilising saponin digitonin, we measured digitonin applications of different concentrations in cytotoxicity assays over 18 h alone to normalise the data of the combination treatment of EGCG and digitonin against the toxic effect the adjuvant already determines alone.

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  • Addition of 40 µg/ml or 50 µg/ml digitonin resulted in similar concentration curves as application of EGCG alone during the first 10 h.

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  • It is likely that besides causing membrane disruption digitonin promotes the transport of EGCG inside the parasite.

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  • In order to verify this methodology, we probe here the effect of EGCG in combination with the adjuvant digitonin as a membrane permeabilising agent on Effect of EGCG on Plasmodium Sporozoite Survival, Motility, and Liver Cell Infection

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  • The values were averaged over triplicates (each containing 200 to 300 parasites) and normalised to the cytotoxicty assay of 40 µg/ml to 70 µg/ml digitonin without EGCG application measured over

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  • A clear shift towards an increased toxic effect of EGCG by digitonin application was only reached by a combination of EGCG with 60 µg/ml or 70 µg/ml digitonin.

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  • At a higher EGCG concentration (200 µg/ml) the additional effect of digitonin was more pronounced and detected already after less than 2 h.

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  • Following, 25 µl of EGCG (Sigma) or digitonin (Sigma) were mixed with 2 µl SYTOX-Orange (100 µM stock, Invitrogen) and added to the parasite solution.

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