“Seven years after this change, we investigated the prevalence of dihydropteroate synthase (dhps) and dihydrofolate reductase (dhfr) mutations, known to be associated with decreased sensitivity to SP, in 173 asymptomatic Plasmodium falciparum infections from Salima, Malawi.”
“Published data from children and pregnant women in Blantyre over the study period show that "quintuple" mutant parasites with two mutations in the dihydropteroate synthase (dhps) gene and three dihydrofolate reductase (dhfr) mutations were highly prevalent in Blantyre over the study period”
“In this part of the Amazon basin, it may be possible to predict treatment failure with sulfadoxine-pyrimethamine equally well by determination of either of the single mutations dihydrofolate reductase 164L or dihydropteroate synthase”
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