downregulation love

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun genetics The process, in the regulation of gene expression, in which the number, or activity of receptors decreases in order to decrease sensitivity

Etymologies

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Examples

  • The logical first step, then, is to protect the cell before damage occurs, including the cell membrane, mitochondria, and DNA, as well as the downregulation of inflammatory genes.

    Forever Young M.D. Nicholas Perricone 2010

  • As insulin loses function, more insulin is required, more insulin leads to more downregulation of receptors, all of which ultimately leads to obesity.

    Changing dietary trends and the obesity epidemic | The Blog of Michael R. Eades, M.D. 2008

  • In gaining muscle mass, one of his recommendations is to “drop calories by 50% one day per week to prevent protein uptake downregulation.”

    Intermittent fasting guest blog | The Blog of Michael R. Eades, M.D. 2008

  • Moreover, co-expression of both rat α-syn and α-syn siRNA partially reversed the neurodegenerative and behavioral effects of α-syn plays an important role in the rat SNc and suggest that both up - and downregulation of wild-type

    Naturejobs - All Jobs 2010

  • Examination of various SNc neuronal markers indicated that neurodegeneration was due to cell loss and not just downregulation of DA synthesis.

    Naturejobs - All Jobs Oleg S Gorbatyuk 2010

  • One study has also shown that dexamethasone (DEX) contributed to the downregulation of MAM-induced IL1B and TNF -.

    PLoS ONE Alerts: New Articles Gang Wu et al. 2010

  • Da Silva AP, Pollett A, Rittling SR, Denhardt DT, Sodek J, et al. (2006) Exacerbated tissue destruction in DSS-induced acute colitis of OPN-null mice is associated with downregulation of TNF-alpha expression and non-programmed cell death.

    PLoS ONE Alerts: New Articles Donald Courter et al. 2010

  • Examination of various SNc neuronal markers indicated that neurodegeneration was due to cell loss and not just downregulation of DA synthesis.

    Naturejobs - All Jobs 2010

  • A key proposition that underpins our understanding of dosage sensitivity is that duplication or deletion of the genomic region containing a gene will result in a significant up - or downregulation of expression of the gene

    PLoS ONE Alerts: New Articles Benjamin Schuster-B�ckler et al. 2010

  • Does the downregulation of the FGF23 signaling pathway in hyperplastic parathyroid glands contribute to refractory secondary hyperparathyroidism in CKD patients

    Naturejobs - All Jobs Marie-Hélène Lafage-Proust 2010

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