“Benzene has this wonderful habit of intercolating into dsDNA and causing strand breaks — nasty nasty business.”
“The genetic material can be dsRNA, ssDNA, or dsDNA between 5 and 500 kilo base pairs long with either circular or linear arrangement.”
“At Week 76, the median percent reduction in anti-dsDNA was 49.5% for belimumab 10 mg/kg, 43.3% for belimumab 1 mg/kg, and”
“Reduction in anti-dsDNA of 29.4% at Week 52 and 63.0% at”
“Among patients who were positive for anti-double-stranded DNA autoantibodies (anti-dsDNA) at baseline, a significantly greater median percent reduction in anti-dsDNA was observed among patients in the belimumab treatment groups vs. the placebo group, with reductions observed by”
“The Phase 3 development program for belimumab included two double-blind, placebo-controlled, multi-center Phase 3 superiority trials - BLISS-52 and BLISS-76 - to evaluate the efficacy and safety of belimumab plus standard of care, versus placebo plus standard of care, in seropositive (HEp-2 ANA ≥ 1: 80 and/or anti-dsDNA ≥ 30 IU/mL) patients with SLE.”
“Photoluminescence enhancement is demonstrated at the single molecule level for two-particle systems composed of a quantum dot (Qdot) and gold nanoparticle (AuNP) linked by double stranded DNA (dsDNA) when optically excited with wavelengths within the surface plasmon resonance range of the gold nanoparticle.”
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