from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. (biochemistry) Any heterocycle containing a peroxide -O-O- residue in the ring; found especially in certain intermediates in prostaglandin biosynthesis.
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It does this by irreversibly blocking the enzyme cyclooxygenase (COX), which catalyzes the conversion of arachidonic acid to endoperoxide compounds.
Prostaglandin endoperoxide H synthases (PGHSs) 1 and 2, also known as cyclooxygenases (COXs), catalyze the oxygenation of arachidonic acid (AA) in the committed step in prostaglandin
Variants of two genes were associated with increased risk of kidney cancer: nitric oxide synthase 2A (NOS2A), which increases levels of nitric oxide, a chemical that promotes free radical damage to cells; and prostaglandin-endoperoxide 2 (PTGS2), which produces prostaglandins, compounds that cause inflammation.
The uterine infection caused a massive (~90-fold) upregulation of the prostaglandin-endoperoxide synthase 2/cyclooxygenase-2 gene (PTGS2) (
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