Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun Any of a class of
bacterial products characterized by nine- or ten-memberedrings containing twotriple bonds separated by adouble bond , many of which are highlytoxic toDNA and used asantitumour agents.
Etymologies
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Examples
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Except for minor protease activating effect of AB-3 towards PC7, all other enediyne compounds exhibited inhibitory effects towards furin, PC5 and PC7 with IC
PLoS ONE Alerts: New Articles Ajoy Basak et al. 2009
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Due to this unique ability to cyclize and produce reactive bis-radicals, several enediyne derivatives have been designed as reactive species especially for DNA degradation
PLoS ONE Alerts: New Articles Ajoy Basak et al. 2009
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Kar M, Mandal S (2005) Dependence of reactivity of a novel 2,6-diamino pyridine-based enediyne on the extent of salt formation with external acids: a possible implication in pH based drug design.
PLoS ONE Alerts: New Articles Ajoy Basak et al. 2009
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Most aromatic enediyne compounds are chemically highly reactive and can easily generate upon heating reactive bis-radical species
PLoS ONE Alerts: New Articles Ajoy Basak et al. 2009
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This is the first report of PC-inhibitory activity of an enediyne compound
PLoS ONE Alerts: New Articles Ajoy Basak et al. 2009
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Among the compounds tested, a 12-membered 1, 4-diaza enediyne heterocyclic ring compound with bis-benzyl substituent (AB-2) has been found to exhibit highest inhibitory activities against both furin and PC7 with IC
PLoS ONE Alerts: New Articles Ajoy Basak et al. 2009
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In a recent study Jones et al. examined the viability of proteins as targets of thermally and photo-activated enediyne derivatives and confirmed at the molecular level.
PLoS ONE Alerts: New Articles Ajoy Basak et al. 2009
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To test this hypothesis, we first synthesized several aromatic enediyne derivatives
PLoS ONE Alerts: New Articles Ajoy Basak et al. 2009
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The table shows the IC50 values for inhibition of recombinant proprotein convertases furin, PC5 and PC7 by various aromatic enediyne compounds.
PLoS ONE Alerts: New Articles Ajoy Basak et al. 2009
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They have shown that specifically designed enediyne derivatives can degrade proteins under suitable conditions
PLoS ONE Alerts: New Articles Ajoy Basak et al. 2009
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