“Today there are 25 drugs in the anti-HIV arsenal, and the 42-year-old New Yorker is holding his ground with a four-drug cocktail that includes a costly new lifesaver called enfuvirtide (Fuzeon).”
“Both studies in treatment-experienced patients were conducted in clinically advanced, 3-class antiretroviral-experienced (NRTI, NNRTI, PI, or enfuvirtide) adults with evidence of HIV-1 replication despite ongoing antiretroviral therapy.”
“Motivators and barriers to prescribing SIAT were identified from statistical analysis of the associations between physicians 'ratings of enfuvirtide-based therapy compared to standard oral-based therapy and 2 indicators of enfuvirtide prescribing behavior.”
“Patients 'attitudes were assessed by their responses to a written profile of enfuvirtide and their ratings of the likelihood of accepting a treatment offer.”
“Valproic acid, a relatively weak HDACI, was tested in a small clinical trial in combination with antiretroviral therapy intensified with the fusion inhibitor enfuvirtide [35, 36], but some more recent studies have failed to show a decay of resting CD4+ T cell infection in individuals under valproic acid treatment for clinical reasons while also receiving standard ART .”
“We analyzed pooled data from week 48 from the two studies according to sex, race or ethnic group, clade, CC chemokine receptor 5 (CCR5) delta32 genotype, viral load at the time of screening, the use or nonuse of enfuvirtide in optimized background therapy (OBT), the baseline CD4 cell count, the number of active antiretroviral drugs coadministered, the first use of selected background agents, and tropism at baseline.”
“The Kaiser Permanente study showed that patients maintained HIV suppression on raltegravir as well as they had on enfuvirtide, and in addition were significantly more satisfied with the new therapy.”
“Nonprescribing was associated with: (1) the belief that offering enfuvirtide would be perceived negatively by patients, leading to treatment refusal and nonadherence; (2) the belief that prescribing enfuvirtide is harder to justify in terms of time / resources; and (3) a lack of confidence in the efficacy and use of enfuvirtide in practice (all p”
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