“These chromatin parts are termed euchromatin and typically located in the nuclear interior.”
“In normal non-dividing cells, DNA is typically packaged into chromatin, which arranges the DNA into a unique order where the more condensed DNA, heterochromatin, is located on the periphery, while the less dense euchromatin, which is where the genes are active, is found in the centre.”
“Most researchers thought heterochromatin had little or no function, because it appeared to lack the protein-coding genes that occur so richly in the chromosomes 'more accessible and better-studied euchromatin," says Karpen, a senior scientist in Berkeley Lab's Life Sciences Division and an adjunct professor of cell and molecular biology at the University of California at Berkeley.”
“In non-dividing cells, DNA is associated with proteins to form the so-called chromatin, with more condensed “heterochromatin” at the periphery and less condensed “euchromatin” in the interior.”
“Prokofyeva, on the degree of extension, synaptic properties, etc., of euchromatin in its neighborhood, effects which she showed to be subject to similar vacillations, that are correlated with the variations in the phrenotypically observed position effects.”
“Their results expand the established break-up of chromatin into euchromatin and heterochomatin to a more complex pattern and link it to histone modifications.”
“An interdisciplinary team of researchers at the LMU, the Max Planck Institute for Brain Research in Frankfurt and the Cavendish Laboratory in Cambridge could show that in nocturnal mammals the chromatin arrangement in the rod nuclei is inverted: Here the heterochromatin is lumped in the nuclear interior whereas the less compacted euchromatin with the active DNA regions forms a peripheral shell.”
“A possible advantage of the conventional architecture is that the central positioning of the active eurochromatin allows more interactions between neighbouring gene loci and with the transcription apparatus in three dimensions; euchromatin in a peripheral shell factually has only two dimensions for contacts.”
“Nevertheless, most cell nuclei follow a general rule where euchromatin is located in the interior, in various compartments that are dense with transcription factories, RNA processing machinery, and many other components.”
“In general, C-bands and G-bands are complexed with proteins and RNAs to give a more compact organization called heterochromatin, whereas R-bands have a more open conformation referred to as euchromatin.”
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