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“Macrophages and fat cells produce powerful substances called tumor necrosis factor-alpha and interleukin-6, which help regulate the immune system.”
“Tobinick believes the drug may work in the brain by blocking an excess of tumor necrosis factor-alpha or TNF-alpha, which may affect communication in the brain.”
“Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramide.”
“In arthritic joints CRP production reflects the release of proinflammatory cytokines, such as interleukins-1 and -6 (IL-1 and IL-6) and tumor necrosis factor-alpha (TNF-alpha), which are essential in the mechanism of cartilage degeneration.”
“Data from a 12-month study known as ATTAIN showed strong efficacy in patients who did not respond to tumor necrosis factor-alpha inhibitors.”
“Cells were incubated for a further 5 h in the basal or stimulated state following the addition of tumor necrosis factor-alpha 0.2 ng/ml.”
“The study found that the hearts of the O3-exposed rats had increased levels of tumor necrosis factor-alpha (TNF α), an indication of inflammation compared to hearts of the control rats.”
“Levels of the pro-inflammatory compounds interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) significantly decreased following 12 weeks of supplementation with”
“Shin JM (2007) Identification of genomic targets downstream of p38 mitogen-activated protein kinase pathway mediating tumor necrosis factor-alpha signaling.”
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