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farnesyltransferase

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. One of the three enzymes in the prenyltransferase group, believed to play an important role in development of progeria and various cancers.

Etymologies

farnesyl +‎ transferase (Wiktionary)

Examples

  • Tipifarnib is classified under drugs known as farnesyltransferase inhibitors (FTIs), which are being tested in people with myeloid leukemia, neurofibromatosis and other conditions.

    Anti-Cancer drug reverses fatal cardiovascular damage linked to progeria

  • Tipifarnib belongs to a class of drugs known as farnesyltransferase inhibitors (FTIs), which are being tested in people with myeloid leukemia, neurofibromatosis and other conditions.

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  • In our experiments, inhibition of c-Ras by farnesyltransferase inhibitors and a dominant negative form of H-Ras (Ras S17N) suppressed muscle differentiation.

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  • Salirasib is not a farnesyltransferase inhibitor (FTI) or Epidermal Growth Factor Receptor

    GuruFocus Updates

  • The farnesyltransferase inhibitor (FTI) tipifarnib is effective in some patients with refractory or relapsed acute myeloid leukemia (AML), according to a report in the June 15th issue of Blood.

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