from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Any substance used to fuse the membranes of cells or protoplasts
Sorry, no etymologies found.
Whereas most other enveloped viruses use a single viral catalyst called a fusogen, herpes viruses inexplicably require two conserved fusion-machinery components, gB and the heterodimer gH-gL, plus other nonconserved components. gB is a class
Scientists have known that the herpes virus fusogen does not act alone, requiring a complex of two other viral cell-entry proteins.
III viral fusogen, but, unlike other members of its class, it does not function alone.
"This unexpected result leads us to believe that this protein complex is not a fusogen itself but that it regulates the fusogen," said senior author Ekaterina Heldwein, assistant professor of molecular and microbiology at Tufts University School of Medicine.
"We also found that certain antibodies interfere with the ability of this protein complex to bind to the fusogen, evidence that antiviral drugs that target this interaction could prevent viral infection."
School of Veterinary Medicine. "gH-gL is an unusually tight complex with a unique architecture that, unexpectedly, does not resemble any known viral fusogen."
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