Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun medicine An
antiviral drug used to treatcytomegalovirus infections
Etymologies
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Examples
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Then, they injected harmless viruses carrying the genes for Fms-like tyrosine kinase 3 ligand (Ftl3L; a protein that attracts dendritic cells) and for thymidine kinase (TK; cells expressing TK are killed by a drug called gancyclovir) into the tumor.
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These agents, which include famciclovir, gancyclovir, acyclovir, and lobucavir, are being tested in clinical trials throughout the world.
DR. SANJIV CHOPRA’S LIVER BOOK Sanjiv Chopra 2001
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Patented drugs like fluconazole, gancyclovir, aciclovir and AZT could alleviate the Aids epidemic but were too expensive for the state to make widely available, TAC said.
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Herein we demonstrate that codelivery of TK (+ systemic gancyclovir [GCV]) to kill glioma cells and release putative endogenous TLR ligands, with Flt3L to attract DCs to the brain, results in a powerful, CD8+ T cell-mediated systemic immune response that elicits tumor regression and immunological memory.
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We demonstrated that HMGB1 was released from dying tumor cells, in response to Ad-TK (+ gancyclovir [GCV]) treatment.
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Expression of both Flt3L and TK (but not of either protein alone) plus gancyclovir treatment shrank the tumors and greatly improved the survival of the mice.
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Of 800 G418 (neomycin) and gancyclovir-resistant colonies, 3 were identified as homologous recombinants with cointegration of the second loxP site by Southern blot analysis of BamHI-digested DNA, using a probe spanning the exon 5 as 5′ external probe (
PLoS ONE Alerts: New Articles Katherine Drews-Elger et al. 2009
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