Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun genetics The state of a
diploid organism having only a single copy of a particulargene , the other copy being inactivated due tomutation
Etymologies
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Examples
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Veitia RA (2002) Exploring the etiology of haploinsufficiency.
PLoS ONE Alerts: New Articles Benjamin Schuster-B�ckler et al. 2010
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Finally, haploinsufficiency as well as duplication sensitivity are likely to affect those master-regulators controlling the balanced expression of a range of other proteins
PLoS ONE Alerts: New Articles Benjamin Schuster-B�ckler et al. 2010
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Our data confirm that, although additive effects of haploinsufficiency at several genes may contribute to the full craniofacial or neurocognitive features of WBS, correct expression of GTF2I is one of the main players.
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Deutschbauer AM, Jaramillo DF, Proctor M, Kumm J, Hillenmeyer ME, et al. (2005) Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast.
PLoS ONE Alerts: New Articles Benjamin Schuster-B�ckler et al. 2010
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Combined haploinsufficiency for both genes resulted in an even larger effect on apoptosis.
BioMed Central - Latest articles Fengtao Su 2010
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Our data confirm that, although additive effects of haploinsufficiency at several genes may contribute to the full craniofacial or neurocognitive features of WBS, correct expression of GTF2I is one of the main players.
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If feedback regulation were predominant, transcription factor haploinsufficiency in humans would be less common.
Naturejobs - All Jobs Michael Springer 2010
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Giaever G, Shoemaker DD, Jones TW, Liang H, Winzeler EA, et al. (1999) Genomic profiling of drug sensitivities via induced haploinsufficiency.
PLoS ONE Alerts: New Articles Arne B. Gjuvsland et al. 2010
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In the presence of strong compensatory mechanism that maintain protein levels, drug-induced haploinsufficiency would still be observed due to saturation of feedback mechanisms.
Naturejobs - All Jobs Michael Springer 2010
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Combined haploinsufficiency for both genes resulted in an even larger effect on apoptosis.
BioMed Central - Latest articles Fengtao Su 2010
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