from The American Heritage® Dictionary of the English Language, 4th Edition
- n. An antihypertensive drug, C8H8N4.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. an antihypertensive drug (trade name Apresoline) that dilates blood vessels; used (often with a diuretic) to treat hypertension and congestive heart failure
Certain drugs, notably hydralazine, which is used to treat hypertension, and procainamide, which is used to treat irregular heartbeat, can trigger lupus attacks in people who have no history of the disease.
PERSONALIZED RESPONSE 1. BiDil is a combination of two generic drugs: isosorbide dinitrate and hydralazine I/H.
Taylor et al., “Combination of isosorbide dinitrate and hydralazine in blacks with heart failure,” New England Journal of Medicine 351 2004, 2049–2057.
African-Americans seem to benefit less than Caucasians from ACE inhibitors, but respond better to a combination of two older drugs -- hydralazine and nitroglycerin -- that are now being marketed as a single pill under the name BiDil.
Duster, president of the American Sociological Association, writes that research on isosorbide dinitrate and hydralazine (BiDil), produced by NitroMed, incorrectly links a biological idea of race to heart disease and that socioeconomic factors better explain susceptibility to heart disease.
- If no improvement after one week: hydralazine (PO): 100 mg/d divided in 3-4 doses (up to double this if needed) or methyldopa (PO): 750 to 1500 mg/d divided in 3 doses
- Eclampsia hydralazine (ampoule de 20 mg/ml, 1 ml) in infusion, protect from light, 4 ampoules of 20 mg in 500 ml 5 % glucose, delivered at 30 drops/minute, until normal BP achieved.
- Infusion: dilute 4 ampoules in 500 ml sodium chloride 0.9%; increase infusion rate progressively up to 30 drops/minute; do not dilute in glucose solutions which inactivates hydralazine.
NicOx is not acquiring any rights to BiDil (isosorbide dinitrate / hydralazine hydrochloride).
Strengthened recommendations on two medications, hydralazine and isosorbide dinitrate, which relieve pressure on the heart by relaxing blood vessels and are particularly effective in African Americans
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